In 1986 Detroit, Demetrius Holloway quickly rose to become one of Detroit's most notorious drug kingpins with the help of a gang started by four brothers, Rockin' Reg, Boogaloo, Ghost, and Wizard Brown, known throughout Detroit as the Best Friends. But when the Best Friends decide to go into business for themselves, it becomes all-out war between Holloway and the brothers. Childhood friends become bitter enemies, and the resulting bloodshed would transform the Motor City into Murder City.